DIAGNOSTICS - REmark


RIBOFLAVIN BASED SOLUTION, ALTERNATIVE TO FLUORESCEIN

REMARK IS A PATENTED OPHTHALMIC SOLUTION BASED ON RIBOFLAVIN, USED FOR TONOMETRY AND OCULAR SURFACE DIAGNOSIS BY TEAR FILM STAINING. 

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REmark


The alternative to fluorescein

Thanks to the fluorescence properties of its components, REmark ® can diagnose ocular mechanisms, ocular pressure by Goldmann Tonometry, contact lenses fitting, tear film Break Up Time evaluation, and other measurements.

Using yellow-green fluorescence properties (up to 565 nm) of its components, REmark ® allows the visualization when illuminated with the cobalt filter used in slit lamps.

REmark ® can be used with wearable contact lenses.

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THE ALTERNATIVE TO FLUORESCEIN

Patented formulation based on Riboflavin

Thanks to the fluorescence properties of its components, can diagnose ocular mechanisms, ocular pressure by Goldmann Tonometry, contact lenses fitting, tear film Break Up Time evaluation, and other measurements.

Using yellow-green fluorescence properties (up to 565 nm) of its components, REmark ® allows the visualization when illuminated with the cobalt filter used in slit lamps.

REmark ® can be used with wearable contact lenses.

INDICATIONS

REmark can be used in:

REmark ® can be used in:

  • Goldmann Applanation Tonometry
  • Ocular surface detection of:
    • Contact lenses evaluation
    • Abnormal tear production
    • Infections
    • Dry Eye
    • Break-Up Time measurement
    • Epithelial abrasions
    • Ulcers
    • Thin tear meniscus
    • Corneal Integrity loss
    • Traumas
    • Conjunctival integrity loss
    • Blocked tear ducts
    • Corneal Oedema
    • Foreign bodies

RIBOFLAVIN AS AN EYE STAIN

Riboflavin is a stain similar to fluorescein, and administered like an eye drop has demonstrated to provide diagnostic information similar to the double staining with fluorescein + lissamine green while being more tolerated. Riboflavin has already been widely used in ophthalmic applications and can be also used in ocular pressure measurements by Goldmann applanation tonometry, with fluorescence characteristics similar to fluorescein based products.

Diagnostic riboflavin has several advantages compared to fluorescein:

  • Has a ten-time longer permanence on the ocular surface, that can allow for the detection of light epithelial abnormalities, and a better analysis of tear film turnover and black line presence;
  • Riboflavin stains the whole tear (not just the aqueous part, like fluorescein does) and provides reliable qualitative information via BUT analysis;
  • Can detect epithelial stressed areas of both cornea and conjunctiva, avoiding the need to use both fluorescein and lissamine green;
  • Riboflavin can be used as a diagnostic stain even in the presence of soft contact lenses, because the staining is temporary, unlike fluorescein, that has to be macro-molecular;
  • Riboflavin stains without side effects or ocular surface damages;

BIBLIOGRAPHY

  1. M. Rolando, F. Bruzzone. “Un’alternativa alla fluoresceina per la misurazione del tono oculare mediante il tonometro di Goldmann”. Italian Review of Ophthalmology, June 2016. [PDF]
  2. POS-32122 “A new biological coloration for corneal and conjunctival evaluation of epithelial injuries”. ESCRS, Copenhagen 2016.[PDF]
  3. P. Troiano, C. Caruso, S. Troisi “La colorazione della superficie oculare” Notiziario SOI 2017-01.[PDF]